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1167366 canonical molecules, 1169461 original records. Five selected targets in order AA2AR/HDAC8/ACES/CSF1R/XIAP; one existing search seed 100. Budget 116946 per target (10% of original records), 584730 across five runs per method. Mean curves equally weight targets at the same per-target budget; sample SD describes target spread, not seed uncertainty. Individual-target SD is undefined (null). The objective minimizes raw docking score, with no QED penalty, DrugCLIP 0%, and target priors disabled. BASE14 explicitly retains the evaluated rank-balanced policy, fixed H1024, batch 300, 180 exploitation plus 120 conditional-exploration proposals per nonterminal batch. The 50-molecule initialization and all unavailable calls remain charged. RAD searched the original library; metrics are replayed on current canonical membership, preserving duplicate/unavailable charges. No compatible verified DUDE-Z Mobley reference exists. Recall/AUC curves use the full charged trajectories before sampling; no extrapolation. Budget savings use 1-primaryBudget/116946, not the reference first-crossing budget. HDAC8 Recall@100 never reaches RAD 98% within the horizon (BASE14 final 97%); its primaryBudget is null. Measured search seconds in target order: BASE14 929.180/854.421/827.686/875.852/832.396; RAD cached traversal prefix 3.839980/3.545723/3.537150/3.641180/4.164799. BASE14 mean search 863.907s, target sample SD 41.226s. Search timings exclude catalogue/preparation and workflow overhead; RAD also excludes graph construction/loading and membership replay. Compatible end-to-end RAD timings are unavailable. Inspected seed and selected targets provide descriptive development evidence, not a 43-target estimate or independent quality confirmation."}]}